Breast Cancer Researchers Find link in Bacteria Imbalance

As attention keep gearing towards raising awareness on cancers in the month of October, Researchers in the United States have uncovered differences in the bacterial composition of breast tissue of healthy women as opposed to those with cancerous tumor.

The team has also discovered that healthy breast tissue contains more of the bacterial species Methylobacterium, a finding that could offer a new perspective in the battle against breast cancer.

The World Health Organisation (WHO) notes that breast cancer caused 571,000 deaths in 2015 and is the top cancer in women globally.

Although it has been previously been discovered that  bacteria that live in the body, known as the microbiome, influence many diseases.

 

However, most research has been done on the “gut” microbiome, or bacteria in the digestive tract and Scientists have long suspected that a “microbiome” exists within breast tissue and plays a role in breast cancer, but it has not yet been characterized.

The research team at Cleveland Clinic, has this taken the first step toward understanding the composition of the bacteria in breast cancer by uncovering distinct microbial differences between healthy and cancerous breast tissue.

According to the chair of Cleveland Clinic’s Genomic Medicine Institute and director of the Center for Personalized Genetic Healthcare,who is also a co-senior author,  Charis Eng M.D PhD, “To my knowledge, this is the first study to examine both breast tissue and distant sites of the body for bacterial differences in breast cancer.

“Our hope is to find a biomarker that would help us diagnose breast cancer quickly and easily. In our wildest dreams, we hope we can use microbiomics right before breast cancer forms and then prevent cancer with probiotics or antibiotics.”

Published online in Oncotarget on Oct. 5, 2017, the study examined the tissues of 78 patients who underwent mastectomy for invasive carcinoma or elective cosmetic breast surgery.

They also examined oral rinse and urine to determine the bacterial composition of these distant sites in the body.

In addition to the Methylobacterium finding, the team discovered that cancer patients’ urine samples had increased levels of gram-positive bacteria, including Staphylococcus and Actinomyces. Further studies are needed to determine the role these organisms may play in breast cancer.

Co-senior author Stephen Grobmyer, M.D. said: “If we can target specific pro-cancer bacteria, we may be able to make the environment less hospitable to cancer and enhance existing treatments.

Larger studies are needed but this work is a solid first step in better understanding the significant role of bacterial imbalances in breast cancer.” Dr. Grobmyer is section head of Surgical Oncology and director of Breast Services at Cleveland Clinic.

The study provides proof-of-principle evidence to support further research into the creation and utilization of loaded submicroscopic particles (nanoparticles), targeting these pro-cancer bacteria.

Funded by a grant from the Center for Transformative Nanomedicine, Drs. Grobmyer and Eng are working with researchers in the Middle East to develop new treatments using nanotechnology to deliver antibiotics directly to the bacterial community in breast cancer.

The study was funded by a Clinical Research Mentorship Award from the Doris Duke Charitable Foundation, The Society of Surgical Oncology Foundation, Cleveland Clinic’s Taussig Cancer Institute, Earlier.org, and Randy and Ken Kendrick. Dr. Eng holds the Sondra J. and Stephen R. Hardis Endowed Chair of Cancer Genomic Medicine at Cleveland Clinic.

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